Vader made his debut in the American Wrestling Association (AWA) in 1985. He went by the moniker Baby Bull, which was later changed to Bull Power. He was eventually put in a match with Stan Hansen for the AWA World Heavyweight Championship, where he was defeated.
Vader signed with World Championship Wrestling (WCW) in 1990, as Big Van Vader, but was only used sparingly until 1991. Vader's first match in WCW took place on July 7, 1990, at The Great American Bash, where he defeated Tom Zenk in a little over two minutes. Seven months later, he returned for WrestleWar, where he battled Stan Hansen to a double disqualification. Eight months later, he returned at Halloween Havoc and took part in the Chamber of Horrors match, in which Vader's team lost due to Abdullah the Butcher being electrocuted by their partner, Cactus Jack. Two months later, he would take part of Starrcade's Lethal Lottery, where he teamed with Mr. Hughes and defeated Rick Steiner and The Nightstalker (who was subbing for an injured Diamond Studd) to advance to the Battlebowl battle royal, in which he was eliminated.
When he began working for WCW full-time, Vader was paired with a manager, Harley Race, and received a shot at Sting's World Heavyweight Championship on April 12, 1992, and was disqualified. Sting suffered a pair of cracked ribs and a ruptured spleen in the match after taking a Vader Bomb from Vader, though he continued to compete infrequently while recuperating. Vader received a rematch with Sting on July 12 at The Great American Bash, which he won to become the new WCW World Heavyweight Champion. His reign was short-lived, as he re-injured his knee, forcing him to lose the title three weeks later to Ron Simmons, who substituted for Sting after he was attacked by Jake Roberts earlier that night. Vader was out of action after Clash of the Champions in September as he underwent knee surgery. Upon his return at Halloween Havoc, Vader sent Nikita Koloff into retirement and legitimately broke the back of jobber Joe Thurman. At Starrcade, Vader lost to Sting in the finals of the King of Cable tournament. Two days later, Vader defeated Simmons by taking advantage of a shoulder injury of Simmons's to regain the World Heavyweight Championship. On March 11, 1993, Vader lost the WCW World Heavyweight Championship to Sting, but regained it six days later.
Upon returning to WCW, Cactus Jack defeated Vader via countout on the April 17, 1993 episode of Saturday Night. During the match, Jack suffered a broken nose and needed twenty-seven stitches on his face. In a rematch on April 24, Vader powerbombed Jack onto the concrete floor outside the ring, resulting in Jack suffering a concussion and temporary loss of feeling in his left hand and leg. In the meantime, Vader began to feud with a new arrival to WCW, Davey Boy Smith. They met at Slamboree in May for the World Heavyweight Championship. Vader lost by disqualification when he hit Smith with a chair, though he retained the title. Vader and Sid Vicious then formed a partnership and called themselves The Masters of the Powerbomb. They were defeated by Smith and his new partner, Sting, at Beach Blast in July. Following this, Vader and Cactus Jack's feud was restarted as Jack was cleared to return for Halloween Havoc to face Vader in a Texas death match. Vader won when Harley Race stunned Jack with a cattle prod that kept him down for a ten count. On March 16, 1994, Jack lost his right ear in a match with Vader in Munich, Germany; Foley's head became trapped in the ropes, which were under excessive tension, causing his ear to be torn off.
Vader was originally scheduled to face Sid Vicious at Starrcade. Vicious' departure from WCW, however, forced WCW to find a quick replacement. Ric Flair was then placed in the match, which was scheduled in Flair's hometown of Charlotte, North Carolina. In the storyline, Vader did not take Flair seriously until he agreed to put his career on the line against Vader's title. Vader dominated the match, but Flair capitalized on failed interference by Race and Vader's weakened knees to win the match with a rollup and end Vader's third World Heavyweight Championship reign.
Vader continued to feud with Flair until SuperBrawl IV, when Flair once again defeated Vader, this time in a "Thundercage" match, with the help of the special guest referee The Boss. As a result, Vader began feuding with Boss, whom he defeated at Spring Stampede. He also faced Sting at Slamboree for the vacant International World Heavyweight Championship. Sting requested the match rather than be awarded the title after an injury to his original opponent, Rick Rude, and defeated Vader. At Bash at the Beach, he defeated the former Boss, now known as The Guardian Angel, by disqualification. Two months later at Fall Brawl, he defeated Angel and Sting in a triangle match to determine the number one contender for the WCW World Heavyweight Championship, now held by Hulk Hogan. A month later at Halloween Havoc, he defeated the Guardian Angel in a rematch. At Clash of the Champions XXIX, Vader defeated Dustin Rhodes and earned the opportunity to face the United States Heavyweight Champion Jim Duggan at Starrcade, where Vader defeated Duggan with the aid of Duggan's 2x4 to win the United States Heavyweight Championship.
In January 1995, Vader had to end his alliance with Harley Race after Race left WCW. Vader confronted the World Heavyweight Champion Hulk Hogan, and informed him that he could not avoid the monster. The two met at SuperBrawl V, with Vader managing to kick out of Hogan's leg drop after a count of one. The referee was knocked out before Vader hit the Vader Bomb on Hogan. Ric Flair ran to the ring, made the three count, and attacked Hogan, resulting in Vader's disqualification. A rematch was signed, a strap match for the inaugural Uncensored pay-per-view. Flair once again intervened (this time in drag to avoid revealing his presence) and managed to cost Vader the match by getting himself carried by Hogan as he touched all four turnbuckle pads. Vader was stripped of the United States Heavyweight Championship on April 23, 1995 for multiple violent offenses. However, Vader gained another opportunity to win the World Heavyweight Championship from Hogan at Bash at the Beach in a steel cage match. He conspired with Kevin Sullivan and the Dungeon of Doom to gain a psychological edge before the encounter, which Vader lost when Hogan escaped the cage. He then restarted his feud with Flair, based on his frustration at Flair's constant interference in his title matches and Flair's annoyance at his inability to defeat Hogan. At Clash of the Champions XXXI, Vader defeated Flair and Arn Anderson in a 2-on-1 handicap match. Following the event, Hogan grew interested in Vader and asked for his assistance in his developing feud with the Dungeon of Doom by asking him to join him, Randy Savage, and Sting for WarGames. Vader complied but the storyline never developed as, shortly after, Vader was fired from WCW.
In the weeks leading up to the 1996 Royal Rumble, Vader's World Wrestling Federation (WWF) debut was heavily hyped on television as he was billed as "The Man They Call Vader". He made his first WWF appearance as a participant in the Royal Rumble match, as he entered at number thirteen and eliminated Jake Roberts, Doug Gilbert, one member of the Squat Team, and Savio Vega; he also fought with his ally Yokozuna, but Vader was eliminated by Shawn Michaels before he re-entered the ring and started assaulting everyone, including Michaels. Vader defeated Vega on the following Monday Night Raw, before assaulting WWF officials and eventually, WWF President Gorilla Monsoon demanded that Vader cease his attacks, but received a Vader Bomb for his efforts. As a result, Vader was suspended for his actions, though in reality he needed time off for shoulder surgery.
Jim Cornette campaigned for Vader's reinstatement, and by the time Vader returned, Yokozuna had left Cornette's management. At February's In Your House 6, Vader appeared during Yokozuna's match against The British Bulldog, and as Yokozuna was about to pin The Bulldog, Vader attacked him, handcuffed him, and delivered a severe beating. This led to what was supposed to be a one-on-one encounter between Vader and Yokozuna at WrestleMania XII. However, the match became a six-man tag team match pitting Vader, Owen Hart, and The British Bulldog against Yokozuna, Ahmed Johnson, and Jake Roberts, with the stipulation that if Yokozuna's team won the match, he would have five minutes alone with Cornette in the ring; this never occurred as Vader's team won the match when Vader pinned Roberts.
Vader then attacked the WWF Champion Shawn Michaels after one of Michaels' matches, which earned him a spot in a six-man tag team match at In Your House 9: International Incident, where Vader, Owen Hart, and The British Bulldog teamed up against Michaels, Ahmed Johnson, and Sycho Sid; Vader pinned Michaels to win the match for his team. Vader faced Michaels again at SummerSlam, where Vader won by countout; Cornette, however, realized that the title could not change hands through a countout and got the match restarted, but this time, Michaels used Cornette's tennis racket and was disqualified, so again, Cornette managed to get the match started over, which Michaels won by pinfall.
Following his feud with Michaels, Vader faced off against The Undertaker in a singles match at the Royal Rumble, and during the match, The Undertaker's former manager, Paul Bearer, attacked him and helped Vader win; Bearer then became Vader's manager. Both Vader and Undertaker went on to compete in the Royal Rumble match, during which Stone Cold Steve Austin was eliminated by Bret Hart; however, the referees did not see this, as they were attending to Terry Funk and Mankind on the floor, allowing Austin to sneak back into the ring and eliminate both Vader and Undertaker, then Bret Hart, who was busy eliminating Fake Diesel, and win the Royal Rumble. As a result of this, Vader and the other men eliminated by Austin, Bret Hart and The Undertaker, were put into the four-way main event of February's In Your House 13: Final Four for the WWF Championship, in which Vader, after bleeding profusely, was eliminated by The Undertaker. Bearer then persuaded his two proteges, Vader and Mankind, to go after the WWF Tag Team Championship, despite the fact that the two men often brawled between themselves. They failed in their bid to win the tag team gold at WrestleMania 13.
Vader again received an opportunity to face The Undertaker, this time for the WWF Championship at In Your House 16: Canadian Stampede, but lost. On the following night's Raw is War, Vader wrestled The Patriot, who won the match and then went after Bret Hart, who came to ringside during the match; Vader attacked The Patriot, and then brought him back into the ring, where he went for the Vader Bomb, but Hart came into the ring and laid the Canadian flag over The Patriot, so Vader got down, picked up the Canadian flag, broke it, and started a brawl with Hart. This turned Vader face and served to bring Vader into the United States versus Canada feud, which culminated at Survivor Series, where Vader was the leader of Team USA, with Goldust, Marc Mero, and Steve Blackman (replacing the injured Patriot) as they faced Team Canada, composed of The British Bulldog, Jim Neidhart, Doug Furnas, and Phil LaFon; during the match, Goldust and Marlena walked out on his team and Team USA lost the match after The Bulldog pinned Vader after hitting him with the ring bell. Goldust and Vader feuded throughout the fall and finally faced off at the Royal Rumble, in a match which Vader won. Goldust eliminated Vader from the Royal Rumble match later that night (Vader entered at number 30).
Following his feud with Goldust, Vader began feuding with Kane, and they both faced off for the first time at No Way Out of Texas, where Vader lost after a chokeslam and a Tombstone Piledriver before Kane subsequently attacked him with a large steel wrench, resulting in Vader being taken away on a stretcher and was kept off of television for a while. Two months later, at Unforgiven, Vader returned during Kane's Inferno match against The Undertaker; as Kane was attempting to leave the match, Vader appeared and fought him back to the ring to continue the match, which Kane lost. Vader and Kane had a rematch at Over the Edge in a mask versus mask match, in which Vader attempted to use a wrench on Kane like the one used on him months before, but Kane managed to recover and defeat Vader, costing him his mask in the process. In a post-match interview with Michael Cole, Vader was visibly upset and questioned if "Vader Time" was over.
Subsequently, Vader had a series of losses and was reduced to the status of a jobber to the stars, having a feud with Mark Henry, which Vader lost. His final WWF pay-per-view match was a loss to Bradshaw at Breakdown: In Your House in a no holds barred match. He lost to Edge on the October 11, 1998 episode of Sunday Night Heat in his final televised WWF match.
Vader returned to the WWF, now World Wrestling Entertainment (WWE), on the October 31, 2005 episode of Raw when Jonathan Coachman announced that Vader and Goldust would be in his corner for his street fight against Stone Cold Steve Austin the next night at Taboo Tuesday. When Austin decided not to participate, he was replaced by Batista. Vader and Goldust interfered in the match on Coachman's behalf and received spinebusters for their efforts.
On the June 11, 2012 episode of Raw, Vader defeated Heath Slater in a singles match. On July 23, on the 1000th episode of Raw, Vader and several other legends prevented Slater from leaving in his match against Lita, which she won.
In April 2016, Vader made a one-night appearance at the 2016 WWE Hall of Fame ceremony to induct Stan Hansen into the WWE Hall of Fame.
On June 18, 2018, Vader passed away.
On March 7, 2022, it was announced that Vader would be inducted into the WWE Hall of Fame himself, posthumously.