In 1966, Parisi began wrestling for the World Wide Wrestling Federation (WWWF), where he was billed as the cousin of Bruno Sammartino, Antonio Pugliese. In this role, he was targeted by several heel wrestlers, who wanted to start feuds with the Sammartino family. On February 21, 1966, Pugliese teamed with Johnny Valentine to win the WWWF United States Tag Team Championship from Dan Miller and Dr. Bill Miller. They held the title belts for nine months before dropping them to the team of Baron Mikel Scicluna and Smasher Sloan on September 22. In this match, Valentine turned on Pugliese by awarding the championship to their opponents when Pugliese was injured.
Pugliese teamed with Miguel Pérez to challenge Scicluna and Sloan for the titles on December 8, but Pérez sustained an injury during the match and was replaced by Spiros Arion. Pugliese and Arion won the match and the titles; they held the belts for six months until June 1967. The team split up when Pugliese left the company briefly, and Arnold Skaaland was named as co-holder of the championship in his place.
Pugliese returned to the WWWF in 1970, under the ring name Tony Parisi. He teamed with Louis Cerdan to win the WWWF World Tag Team Championship on November 18, 1975. They defeated The Blackjacks (Blackjack Mulligan and Blackjack Lanza) to win the belts, and held them for over six months. They eventually dropped the titles in a match against The Executioners (a team composed of Killer Kowalski and Big John Studd, who wore masks to hide their identities) on May 11, 1976. Also in 1976, Parisi teamed with champion Bruno Sammartino in Madison Square Garden to defeat Ivan Koloff and Superstar Billy Graham.When the promotion decided to reactivate the WWF International Heavyweight Championship in 1982, Parisi became the new champion. He lost the belt to his former partner, Gino Brito, that August.
On August 19, 2000, Parisi passed away.