On the May 24, 2010, episode of Raw, The Usos (Jey and Jimmy) made their debut with Tamina as heels by attacking the Unified WWE Tag Team Champions, The Hart Dynasty (Tyson Kidd, David Hart Smith, and Natalya). The following week, Raw General Manager Bret Hart stated that he had signed them to contracts. That night, the trio cut a promo, stating that they were looking for respect for their families. They were interrupted and attacked by The Hart Dynasty, who were seeking revenge for the surprise attack the previous week. The Usos attempted to attack The Hart Dynasty again on the June 7 episode of Raw, but The Harts were ready and gained the upper hand. The Usos made their in-ring debut for the brand on the June 17 episode of Superstars, defeating Goldust and Mark Henry. Three days later they made their pay-per-view debut by losing to The Hart Dynasty in a six-person mixed tag team match at Fatal 4-Way. The Usos were scheduled to face The Hart Dynasty on the June 28 episode of Raw, but the match never started as The Usos instead attacked The Harts when they were entering the ring. The Usos defeated The Hart Dynasty for the first time in a six-person mixed tag team match on the July 12 episode of Raw when Jey pinned Smith. The Usos challenged The Harts for the Unified Tag Team Championship at the Money in the Bank pay-per-view, but were unsuccessful. On the July 26 episode of Raw, Jey Uso went against Randy Orton in his first singles match on the brand in a losing effort. They received another shot for the Tag Team Championship at Night of Champions in a Tag Team Turmoil match, where they eliminated both The Hart Dynasty and the team of Vladimir Kozlov and Santino Marella before being eliminated by Mark Henry and Evan Bourne. On the December 6 episode of Raw, The Usos were in a fatal four-way tag match and were eliminated, but Tamina stayed in the corner of Marella and Kozlov upon their winning of the WWE Tag Team Championship; as a result, she turned face and left The Usos.
On April 26, 2011, both Usos were drafted to the SmackDown brand as part of the 2011 Supplemental Draft. On the June 2 episode of Superstars, The Usos turned face when they competed against The Corre (Justin Gabriel and Heath Slater) in a losing effort. Throughout June 2011, The Usos continued to complete victories with Gabriel and Slater in tag team matches, while managing to defeat them in two six-man tag matches while partnering once with Ezekiel Jackson and once with Trent Barreta.[33] The Usos began performing the Siva Tau, a traditional Samoan war dance, as part of their ring entrance, using the dance to display their strength and energize themselves. On the July 29 episode of SmackDown, The Usos challenged David Otunga and Michael McGillicutty for the WWE Tag Team Titles, but were defeated.
The Usos then began appearing on the fifth season of NXT in September 2011, by delivering post-match attacks on the team of Darren Young and JTG. The Usos then went on to defeat Young and JTG on the September 27 episode of NXT Redemption. However, just like how The Usos debuted on NXT, they were attacked after their win by another debuting tag team, Curt Hawkins and Tyler Reks, and The Usos were defeated by Hawkins and Reks the next week. In the following months and into 2012, The Usos exchanged wins with Hawkins and Reks on NXT, while continually losing to Primo and Epico on SmackDown. They also feuded with JTG, who had become Tamina's boyfriend. In March 2012, The Usos began a feud with Darren Young and Titus O'Neil, after they mocked The Usos' pre-match Siva Tau. Although The Usos beat Young and O'Neil in tag team matches, they were continually defeated in singles matches. On the final episode of the fifth season of NXT on June 13, The Usos defeated Johnny Curtis and Michael McGillicutty.
The Usos then started a feud with The Ascension (Conor O'Brian and Kenneth Cameron) on the August 15 episode of NXT, with a match between the two tag teams ending in the Ascension being disqualified; the Ascension then conducted a post-match attack on The Usos. On the August 29 episode of NXT, The Usos called out the Ascension, but the Ascension ambushed The Usos and again delivered a beatdown. On the September 5 episode of NXT, the Ascension defeated The Usos. The Usos then teamed with Richie Steamboat to lose to The Ascension and Kassius Ohno on the October 17 episode of NXT. The Usos' feud with the Ascension was cut short when Cameron was released from WWE.
At WrestleMania XXVIII, The Usos unsuccessfully challenged for the WWE Tag Team Championship in a triple threat dark match against champions Primo and Epico and Tyson Kidd and Justin Gabriel when the defending champions retained their titles. At No Way Out, The Usos competed with Primo and Epico, Justin Gabriel and Tyson Kidd, and The Prime Time Players in a Fatal-4-Way Tag Team match to determine the Number 1 contenders for the WWE Tag Team Champions and were unsuccessful. On the July 16 episode of Raw, The Usos made an appearance dancing with their father, Rikishi, after Rikishi made a "Blast from the Past" return defeating Heath Slater. On the September 7 episode of SmackDown, The Usos were unsuccessful in winning a Triple Threat Tag Team match for No# 1 contendership for the WWE Tag Team titles against The Prime Time Players, and Primo and Epico.
On the June 3 episode of Raw, The Usos began to use face paint similar to their deceased uncle Umaga, as a means of further highlighting their Samoan culture. During the following months, they competed for The Shield's WWE Tag Team Championship. At Money in the Bank, The Usos challenged Rollins and Reigns for the titles, but were unsuccessful and participated in a Triple threat tag team match against the team of Cody Rhodes and Goldust and The Shield at the Hell in a Cell pay per view, which they failed to win.
The Usos were involved in the traditional Survivor Series elimination match at Survivor Series, teaming with Rey Mysterio, Cody Rhodes and Goldust in a losing effort against The Real Americans and The Shield. After a brief feud against The Wyatt Family, at the beginning of 2014, The Usos would go on a winning streak and began to demand a Tag Team Championship match from The New Age Outlaws. They received a tag title shot at the Elimination Chamber PPV against the Outlaws but were once again unsuccessful, but they won the titles on the March 3 episode of Raw. On the WrestleMania XXX pre-show, The Usos successfully defended their titles in a Fatal Four Way Elimination match against Ryback and Curtis Axel, The Real Americans, and Los Matadores. The Usos then resumed a rivalry with The Wyatt Family, successfully retaining the championships against Harper and Rowan at Money in the Bank and Battleground. The Usos then dropped the titles to Goldust and Stardust at Night of Champions, ending their reign at 202 days.
On the December 29 edition of Raw, The Usos recaptured the titles from The Miz and Damien Mizdow after feuding with them over Naomi's entertainment opportunities. However, they lost the titles at Fastlane against Tyson Kidd and Cesaro. Despite getting a rematch the next night on Raw, The Usos did not regain the titles due to Natalya interfering for a DQ win. At the March 9 SmackDown tapings, Jey Uso suffered a serious shoulder injury, the extent of which was unknown. On the WrestleMania 31 pre-show, they competed in the fatal-four-way tag team match; however, Jey re-injured his shoulder at the hands of Cesaro.
In April, Jey Uso suffered an anterior shoulder dislocation on the left arm and would be out for about six months, putting their team on hiatus. On the April 18 episode of Main Event, Jimmy Uso defeated Xavier Woods. Jimmy performed commentary while Jey was out with the injury. On the May 12 episode of Main Event, Jimmy Uso teamed with Zack Ryder to face Luke Harper and Erick Rowan in a losing effort. Jimmy Uso returned to action on the September 10 episode of SmackDown, teaming with Roman Reigns and Dean Ambrose in a six-man tag team against The New Day (Big E, Kofi Kingston and Xavier Woods). They won via disqualification after Jimmy was attacked by The Wyatt Family (Bray Wyatt, Braun Strowman and Luke Harper).
The Usos came back on the November 2 episode of Raw as a surprise return to team up with Roman Reigns, Dean Ambrose and Ryback against Seth Rollins, Kevin Owens and The New Day in a Survivor Series elimination tag team match, The Usos along with Reigns, Ambrose and Ryback were victorious in the match. On the November 30 episode of Raw, The Usos competed in a tag team #1 contenders match against The Lucha Dragons, which ended in a double disqualification when The New Day attacked both teams. Later that night, Stephanie McMahon gave The Lucha Dragons their match for the WWE Tag Team Championship at TLC and The Usos would get their match if Roman Reigns defeated Sheamus for the WWE World Heavyweight Championship in 5 minutes and 15 seconds, which he won by disqualification. At TLC, The Usos competed in a losing effort. The Usos won a Slammy Award on the December 21 episode of Raw for "Tag Team of the year".
At the 2016 Royal Rumble, The Usos unsuccessfully challenged The New Day for the WWE Tag Team Championship. In February, The Usos entered a feud with The Dudley Boyz after The Dudley Boyz put The Usos through tables after defeating The New Day and Mark Henry in an 8-man Tag team Tables match. On the WrestleMania 32 kickoff show, The Usos defeated The Dudley Boyz, but the next night on Raw, they were defeated by the Dudleys in tables match. On the April 11 episode of Raw, The Usos defeated The Social Outcasts in the first round of a tag team tournament. Following the match, they were attacked by Luke Gallows and Karl Anderson. The following week on Raw, The Usos lost to The Vaudevillains in the semi-final round. On the May 2 episode of Raw, The Usos and Roman Reigns were defeated by AJ Styles, Gallows and Anderson in a six-man tag team match when Styles pinned Jey Uso. At Extreme Rules, The Usos were defeated by Gallows and Anderson in a Texas Tornado match, but they were still able to help Roman Reigns retain his title in the main event.
On July 19, at the 2016 WWE draft, The Usos were drafted to SmackDown. working in the Battleground and SummerSlam pre-shows.Then, they entered an 8 tag team tournament to determine the inaugural holders of the WWE SmackDown Tag Team Championship. On the September 6 episode of SmackDown, The Usos turned heel for the first time since 2011 when they attacked American Alpha after losing to them in 28 seconds in the semi-finals. At Backlash, The Usos faced Heath Slater and Rhyno in the tournament finals, but were defeated. The Usos faced the new champions at No Mercy, where they were defeated again. As part of their heel turn, they began a street-like, thuggish gimmick.
The Usos participated in a 5–on–5 Survivor Series Tag Team Elimination match at Survivor Series, where they lost to Cesaro and Sheamus of Team Raw. The Usos would reignite their feud with American Alpha following Elimination Chamber after they attacked American Alpha. On the March 21st, 2017 episode of SmackDown, The Usos defeated American Alpha to win the SmackDown Tag Team Championship, becoming the first team to have won both the Raw (formerly WWE Tag Team Championship) and SmackDown Tag Team Championship.
On the April 12th episode of SmackDown Live, The Usos were successful in their first title defense by defeating American Alpha in a rematch, ending the feud. They retained the titles at Backlash against Breezango (Tyler Breeze and Fandango) and Money in the Bank against The New Day, but lost them at Battleground to The New Day, ending their 124-day reign. On August 20 at the SummerSlam pre-show, The Usos defeated The New Day to recapture the titles. Their reign ended on the September 12 edition of SmackDown Live after they lost to The New Day in a Sin City Street Fight, but regained at Hell in a Cell.
At Survivor Series, they defeated Raw Tag Team Champions Cesaro and Sheamus in an interbrand Champion vs Champion match. At Clash of Champions, The Usos retained the title in a Fatal 4-way tag team match against Gable and Benjamin, The New Day (Big E and Kofi Kingston) and Rusev and Aiden English. At Royal Rumble, The Usos defended the title against Gable and Benjamin in a 2 out of 3 falls match, winning 2-0 to retain the title. They would renew their rivalry with the New Day, culminating in a title match at Fastlane, which would end in a no-contest due to interference from the Bludgeon Brothers.
At WrestleMania 34, The Usos wrestled on the main card of WrestleMania for the first time, where they defended the titles against The New Day and The Bludgeon Brothers in a triple threat tag team match, but The Usos dropped the belts to The Bludgeon Brothers after Harper pinned Kofi Kingston. On the SmackDown after WrestleMania, the Usos would defeat the New Day to earn a rematch against the Bludgeon Brothers for the WWE SmackDown Tag Team Championship at the Greatest Royal Rumble. At the event on April 27, The Usos were defeated when Rowan pinned Jey Uso.
On the January 29, 2019, episode of WWE SmackDown, they defeated The Bar, The New Day and Heavy Machinery to get a SmackDown Tag Team Championship match at Elimination Chamber where they faced defending champions Shane McMahon & The Miz, where they won the titles. They defended the titles against The Bar, Aleister Black and Ricochet, and Shinsuke Nakamura and Rusev in a tag team fatal 4-way at WrestleMania 35 for the SmackDown Tag Team Championships, where they would retain. Two days later, on the April 9 episode of SmackDown, The Usos lost their titles to The Hardy Boyz. During the 2019 WWE Superstar Shake-up, The Usos were drafted to Raw and defeated Bobby Roode and Chad Gable in a tag team match. They then entered a feud with The Revival. On the May 7 episode of SmackDown Live, Daniel Bryan and Rowan defeated The Usos for the vacant SmackDown Tag Team Championship. At Money in the Bank, Bryan and Rowan faced off against the Usos in a non title match which ended with the Usos emerging victorious at the event. On the May 20 episode of Raw, The Revival defeated The Usos. At Super Showdown, The Usos defeated The Revival. Three days later on Raw, both the Usos and the Revival competed in a triple threat match for the Raw Tag Team Championship against champions Curt Hawkins and Zack Ryder, which the Revival won. The Usos then challenged The Revival for the titles at Extreme Rules, where they were unsuccessful. Following this loss, the Usos disappeared from television for the remainder of the year after legal troubles.
On the January 3, 2020 episode of SmackDown, The Usos returned to television, saving Roman Reigns from an attack from King Corbin and Dolph Ziggler. However they were again removed from television in May, after Jimmy suffered a knee injury in the triple threat ladder match for the SmackDown Tag Team Championships at WrestleMania 36, putting him out for six to nine months, with Jey only appearing sporadically. On the September 4, 2020 episode of SmackDown, Jey Uso returned and replaced Big E in a fatal-four way match against King Corbin, Matt Riddle, and Sheamus, and won to earn a Universal Championship match at Clash of Champions against Roman Reigns, setting up a "cousin vs. cousin" match-up. However, Reigns defeated Jey Uso, when Jimmy Uso came down and threw a white towel for him. Jey was given another title shot against Reigns in a Hell in a Cell "I Quit" match at the namesake event, with the added stipulation that if Jey lost, he would have to follow the orders of Roman Reigns or be kicked out of their family. At the event, Jey lost again after Reigns attacked the injured Jimmy and making Jey say "I quit".
Jimmy officially returned from injury on the May 7, 2021 episode of SmackDown. Jimmy did not approve of the alliance between Jey and Reigns, as he called Jey "Reigns' bitch" and he even wore a t-shirt that said "Nobody's Bitch". The ensuing dissension between the two over Jey's allegiance eventually caused Jey to temporarily walk out on the June 11 episode of SmackDown. Ironically, the following week on the June 18 episode of SmackDown, Jimmy offered his help to Reigns during his Hell in a Cell match with Rey Mysterio, and he rose Reigns' hand after the match. The following week on SmackDown, Jimmy attempted to assist Reigns when Edge attacked him and speared him through the barricade. On the July 9 episode of SmackDown, both Jey and Jimmy showed their alliance with Reigns, thus cementing them both as heels in the process. At Money in the Bank, The Usos were successful in capturing their fifth SmackDown Tag Team Championships from The Mysterios. At SummerSlam, The Usos would defeat The Mysterios in a rematch to retain the SmackDown Tag Championships. At WrestleMania 38, the Usos defeated Shinsuke Nakamura and Rick Boogs to retain their championships. At WrestleMania Backlash, The Usos and Reigns defeated RK-Bro (Randy Orton and Riddle) and Drew McIntyre in a six-man tag team match, after an illegal maneuver from Riegns. On the May 20 episode of SmackDown, they, with outside interference from Reigns, defeated RK-Bro to win the Raw Tag Team Championships, becoming the Undisputed WWE Tag Team Champions. This gave the Usos their third reign as Raw Tag Team Champions (their first since 2014) and made them the only team to hold the Raw and SmackDown titles simultaneously. At Money in the Bank, the Usos retained their titles against the Street Profits in controversial fashion, with the Usos winning by pinfall despite Montez Ford's shoulder being off the mat. A rematch between the teams was scheduled for SummerSlam with a special guest referee, later revealed to be Jeff Jarrett. On July 18, the Usos surpassed the 365-day mark as SmackDown Tag Team Champions, becoming the first team to hold the titles for a continuous reign of one full year. At SummerSlam, the Usos successfully retained against the Street Profits. At Crown Jewel on November 5, The Usos successfully retained the titles against The Brawling Brutes. On the November 11 edition of SmackDown, they defeated The New Day (Kofi Kingston and Xavier Woods) to break the record for the longest reigning tag team champions in WWE, a record previously set by The New Day. At Survivor Series WarGames on November 26, The Bloodline (The Usos, Roman Reigns, Solo Sikoa and Sami Zayn) defeated The Brawling Brutes, Drew McIntyre and Kevin Owens in a WarGames match.
Tensions between The Usos and Zayn resurfaced in subsequent weeks. After Reigns retained the Undisputed WWE Universal Championship at the Royal Rumble against Kevin Owens, The Usos proceeded to beat down Owens and handcuff him to the ring ropes. After refusing to hit Owens, Zayn then hit Reigns with a steel chair, turning face. Jimmy, Sikoa and Reigns attacked Zayn whilst Jey looked on and eventually left the ring in disgust. After the event, Jey declared on Instagram that "he's out" and did not appear on the following episode of SmackDown. Jey would show up on the February 10 episode of SmackDown to retain the SmackDown Tag Team Championship with Jimmy against Braun Strowman and Ricochet. Before the episode ended, Reigns, through Heyman, informed The Usos to stay at home for the following week's episode of SmackDown and Elimination Chamber in Canada. However, Jimmy would be present for the event to assist Reigns in retaining his championship, and Jey would show up to prevent Reigns from hitting Zayn with a chair, which failed.
On the March 6 episode of Raw, Jey showed up in the crowd during Jimmy's match against Zayn which Jimmy lost. Following the match, Jey hugged Zayn and then delivered a superkick to the latter, affirming Jey's allegiance to The Bloodline. The Usos and Sikoa then attacked Zayn before Cody Rhodes ran out to save Zayn. On the March 20 episode of Raw, a reunited Owens and Zayn challenged The Usos for the Undisputed WWE Tag Team Championships at WrestleMania 39, which The Usos accepted. On night one of the event on April 1, The Usos main evented WrestleMania for the first time in their careers, where they lost the titles to Owens and Zayn, thus ending their Raw reign at 316 days and their record SmackDown reign at 622 days. This match also marked the first time a tag team match main evented WrestleMania since its inaugural show. Following their loss, Reigns started ignoring them and depending on Sikoa instead, with Reigns inserting himself and Sikoa into a title match at Night of Champions. They failed to capture the Undisputed WWE Tag Team Championships in their rematch against Owens and Zayn on the April 28 episode of SmackDown.
At Night of Champions, Jimmy turned face after he and Jey cost Reigns and Sikoa the match for the Undisputed WWE Tag Team Championships, with Jimmy superkicking Reigns for mistreating them. Jimmy was officially excommunicated from The Bloodline for his actions at Night of Champions on the June 2 episode of SmackDown during Reigns' 1,000 days Universal Champion celebration. On the June 9 episode of SmackDown, Jey was given a United States Championship opportunity against Austin Theory by Heyman to entice him to leave Jimmy, but lost the match after Jimmy, while saving Jey from Pretty Deadly, mistakenly attacked Jey while aiming for Sikoa who tried to attack Jimmy. On the following week's episode of SmackDown, Jey decided to side with Jimmy and left The Bloodline by kicking Reigns, turning face in the process. The Usos then superkicked both Sikoa and Reigns. At Money in the Bank, The Usos defeated Reigns and Sikoa in a "Bloodline Civil War" tag team match with Jey pinning Reigns. This marked Reigns' first direct pinfall loss since December 2019. At SummerSlam, Jimmy turned on Jey by pulling him out of the ring while he was trying to pin Reigns and superkicked him, allowing Reigns to defeat Jey, turning heel and disbanding The Usos.