In mid-2003, Doug and Danny Basham were promoted to the main World Wrestling Entertainment (WWE) roster. The Basham Brothers debuted on the May 29 episode of SmackDown!, defeating Spanky and Rikishi. The following week, they unsuccessfully challenged the WWE Tag Team Champions Eddie Guerrero and Tajiri in a non-title match. In June, the Bashams debuted Shaniqua as their valet. In October, they began feuding with The APA (Bradshaw and Ron Simmons), defeating them in three consecutive matches, including at No Mercy.
On the October 23 episode of SmackDown!, The Basham Brothers defeated Los Guerreros (Eddie and Chavo Guerrero) to win the WWE Tag Team Championship. They retained the title in a rematch at Survivor Series, and successfully defended the championship in a four-way match against Los Guerreros, Rikishi and Scotty 2 Hotty, and The World's Greatest Tag Team (Charlie Haas and Shelton Benjamin) in December. On the February 5, 2004 episode of SmackDown!, The Bashams lost the title to Rikishi and Scotty 2 Hotty. At No Way Out, the Bashams and Shaniqua lost a handicap match to Rikishi and Scotty 2 Hotty, and Shaniqua was then released from her contract. Over the next several months, The Basham Brothers unsuccessfully challenged for the WWE Tag Team Championship against teams including Rikishi and Scotty 2 Hotty, The Dudley Boyz (Bubba Ray and D-Von Dudley), Charlie Haas and Rico, and Billy Kidman and Paul London.
In November 2004, The Basham Brothers joined John "Bradshaw" Layfield's faction, known as The Cabinet, and became known as the Secretaries of Defense. In January 2005, they won a four-way match to win the WWE Tag Team Championship, defeating Rey Mysterio and Rob Van Dam, Eddie Guerrero and Booker T, and Mark Jindrak and Luther Reigns. A month later, at the No Way Out pay-per-view, they lost the titles to Rey Mysterio and Eddie Guerrero, and failed to regain the championship in a rematch on SmackDown! on February 24. In June, they quit The Cabinet.
Danny would then wrestle in house shows and dark matches for the Raw brand. Doug would begin a singles career, going on to appear on WWE Velocity.
The Basham Brothers reunited on the ECW brand during July 2006 at several house shows before becoming on-screen unnamed masked "Security Enforcers" for ECW leader Paul Heyman. However, when Danny was injured with a torn biceps, he was later replaced by Derek Neikirk, who continued Danny's role as the second masked enforcer. On January 18, 2007, both were released by WWE.