On the August 31, 2010 episode of NXT, it was announced that Naomi would be part of the all-female third season of NXT, with Kelly Kelly as her pro. Naomi debuted on the September 7 episode of NXT, where she teamed with Kelly to face fellow rookie Maxine and Alicia Fox in a winning effort after Naomi pinned Maxine. On the September 21 episode of NXT, she teamed with Kelly and Jamie Keyes, defeating Layla, Michelle McCool, and Kaitlyn. On the October 26 episode of NXT, Naomi defeated Maxine in a singles match. On November 30, Naomi lost the competition to Kaitlyn, placing second in the season.
On the January 9, 2012, episode of Raw, Naomi made her main roster debut alongside Cameron as valets for the returning Brodus Clay, where the duo was dubbed The Funkadactyls. On the TLC pre-show on December 16, Naomi scored a victory in a Santa's Little Helpers battle royal, earning a match against Divas Champion Eve later that night, where she was defeated by Eve.
On the March 15, 2013, episode of SmackDown, The Funkadactyls were attacked backstage by The Bella Twins, starting a feud between the two teams. It was announced on March 27 that The Funkadactyls, Clay, and Tensai, collectively known as Tons of Funk, were set to face Team Rhodes Scholars (Cody Rhodes and Damien Sandow) and the Bella Twins in an eight-person mixed tag team match at WrestleMania 29. After the match was cut due to time constraints, it instead took place the following night on Raw, with Tons of Funk coming out victorious. On the August 26 episode of Raw, Naomi was ringside for a match between Natalya and Brie Bella alongside the cast of Total Divas, which ended with Divas Champion AJ Lee coming out and cutting a worked shoot promo directed at the women. On the September 15, Naomi competed against Natalya, Brie Bella, and Lee in a fatal four-way match for the Divas Championship at Night of Champions, where Lee retained the title. The cast of Total Divas went on to defeat Lee, Alicia Fox, Aksana, Kaitlyn, Rosa Mendes, Tamina Snuka and Summer Rae) in a traditional elimination tag team match at Survivor Series as well as a rematch on the following night on Raw. On December 15 at TLC: Tables, Ladders & Chairs, Naomi, Cameron and Tensai abandoned Clay due to his attitude, effectively disbanding Tons of Funk.
In January 2014, Naomi received a push, facing the Divas Champion AJ Lee in various matches. On the February 3 episode of Raw, Naomi suffered a legitimate displaced fracture of the orbital bone during a match against Aksana. She returned on the March 17 episode of Raw, teaming with Cameron to defeat Lee and Tamina Snuka in a tag team match. On April 6 at WrestleMania XXX, Naomi competed in the Vickie Guerrero Invitational match for Lee's Divas Championship, where Lee successfully retained her title. On the June 17 episode of Main Event, Naomi defeated the new Divas Champion Paige in a non-title match, which led to a championship match at Money in the Bank, in which Naomi was defeated. On the July 7 episode of Raw, Cameron and Naomi lost to Lee and Paige in a tag team match, which caused a brawl to ensue between Cameron and Naomi, officially disbanding The Funkadactyls. After weeks of interfering in each other's matches, Naomi and Cameron faced off on the Battleground pre-show, where Cameron was victorious after she grabbed Naomi's tights. On August 30, Naomi announced on that she had been out of action following minor surgery on her orbital bone. After making her return, Naomi went on to secure victories over Cameron on the September 15 episode of Raw and on the October 9 episode of Superstars. At Survivor Series, Naomi participated in a traditional elimination tag team match, where she eliminated Cameron before eventually pinning Paige to get the win for her team in a clean sweep.
In December, Naomi became involved with The Usos' feud with The Miz, in which Naomi and Jimmy Uso's real-life relationship was acknowledged on-screen. The Miz then began offering to help further Naomi's musical career as well as showing some hints of flirtation, much to Jimmy's dismay. On the December 16 episode of Super SmackDown Live, Naomi competed against Nikki Bella for the Divas Championship, where she lost the match after Jimmy Uso caused a distraction due to his anger of The Miz being present. On the December 29 episode of Raw, she celebrated with her husband and brother-in-law after the Usos won their second WWE Tag Team Championship from The Miz and Damien Mizdow. The storyline continued with Alicia Fox joining The Miz and Mizdow after she attacked Naomi backstage, leading to a series of mixed tag team matches, where Naomi and the Usos repeatedly lost. At Fastlane, Naomi was ringside when The Usos dropped the WWE Tag Team Championship to Tyson Kidd and Cesaro. The following night on Raw, The Usos lost a rematch for the title after a distraction provided by Natalya. On the February 26 episode of SmackDown, Naomi was defeated by Natalya in a singles match. On March 29, she accompanied The Usos during their match on the WrestleMania 31 pre-show, in which they unsuccessfully challenged Kidd and Cesaro for the WWE Tag Team Championship.
On the March 30 and April 6 episodes of Raw, Naomi pinned the Divas Champion Nikki Bella. On the April 13 episode of Raw, Naomi participated in a battle royal to determine the number one contender to the Divas Championship, where she was defeated. After the bout, Naomi attacked Paige for eliminating her to ultimately win the match, turning heel for the first time in her career. After the announcement that Paige had been injured following the attack, Naomi was granted a match against Bella for the title at Extreme Rules, where she failed to win after interference from Brie Bella. In May, Naomi formed an alliance with the returning Tamina. The duo went on to compete in a tag team match against The Bella Twins at Payback, which Naomi and Tamina won. On the May 18 episode of Raw, Naomi competed in another championship match against Nikki Bella, where Bella retained the title after Tamina caused a disqualification. After Paige returned, a triple threat match was made between Naomi, Paige and Nikki Bella at Elimination Chamber, however she once again failed to capture the title.
On the July 13 episode of Raw, after weeks of the Divas division being dominated by The Bella Twins and their ally Alicia Fox for weeks, Stephanie McMahon called for a "Divas Revolution," subsequently introducing the debuting NXT Women's Champion Sasha Banks to align with Naomi and Tamina, as well as Charlotte and Becky Lynch to align with Paige, leading to a brawl between the three teams. The three teams ultimately faced off in a three team elimination match on August 23 at SummerSlam, which was won by Team PCB. Naomi, Tamina and Sasha Banks, known as Team B.A.D. remained together throughout the rest of the year. On the February 1, 2016, episode of Raw, Banks announced her departure from the team, which caused Naomi and Tamina to attack her, officially disbanding the team. The feud continued throughout February, culminating in a tag team match at Fastlane, where Naomi and Tamina lost to Banks and her partner Lynch. On the WrestleMania 32 pre-show, Naomi and Tamina teamed up with Lana, Emma, and Summer Rae in a 10-Diva tag team match against Brie Bella, Paige, Fox, Eva Marie, and Natalya, where Naomi's team was defeated. In early May, Tamina underwent knee surgery in order to repair torn ligaments while Naomi became inactive due to a torn ankle tendon, ending their partnership.
Following a hiatus due to injury and shooting The Marine 5: Battleground, Naomi was drafted to the SmackDown brand as part of the 2016 WWE draft on July 19. She made her first appearance on the July 26 episode SmackDown Live in an in-ring segment involving all of the women of the brand. On the August 16 episode of SmackDown Live, Naomi debuted a new style, entrance, and theme, establishing herself as a face for the first time in over a year. On August 21 at SummerSlam, Naomi competed in a six-woman tag team match alongside Becky Lynch and Carmella against Natalya, Alexa Bliss, and Nikki Bella, where Naomi's team was defeated after Bella pinned Carmella. On September 11 at Backlash, Naomi competed in a six-pack elimination challenge to determine the inaugural WWE SmackDown Women's Champion, where she would eliminate Bliss before she herself was eliminated by Natalya. Naomi was revealed as Bliss's opponent replacing the injured Lynch at No Mercy, where she was victorious. On November 20, Naomi competed as part of the SmackDown women's team against the Raw women's team at the Survivor Series pay-per-view, where Naomi's team was defeated.
After two months of inactivity, Naomi made her return on the January 24, 2017, episode of SmackDown Live, igniting a feud with Bliss. She went on to pin Bliss in tag team matches on two separate occasions at the Royal Rumble and on SmackDown Live. On February 12, Naomi competed against Bliss at Elimination Chamber, where she was victorious, becoming the SmackDown Women's Champion for the first time in her career as well as the first African-American woman to capture the title. The following Tuesday, she was forced to relinquish the title due to a legitimate injury she sustained during the match. On April 2, Naomi made her in-ring return in a six-pack challenge in her hometown of Orlando at WrestleMania 33, where she made Bliss submit, successfully regaining the SmackDown Women's Championship. Two days later, Naomi defeated Bliss in a rematch to retain the championship, ending the feud between the two. On the April 18 episode of SmackDown Live, Naomi was defeated by Charlotte Flair in a non-title match, resulting in Flair earning a match for the SmackDown Women's Championship the following week, which ended in a no contest after an interference by Natalya, Carmella, and Tamina. On May 21, Naomi, Flair, and Lynch were defeated by Natalya, Carmella, and Tamina in a six-woman tag team match at Backlash. On June 18, Naomi defeated Lana to retain the SmackDown Women's Championship at Money in the Bank. She then went on to retain the title over Lana two more times on the June 27 and July 4 episodes of SmackDown Live. In July, Naomi debuted a customized title belt with glow-in-the-dark lights of various colors. On August 20 at SummerSlam, Naomi dropped the SmackDown Women's Championship to Natalya, ending her reign at 140 days. On November 19 at Survivor Series, Naomi competed in a 5-on-5 elimination tag team match, where she eliminated Raw team captain Alicia Fox, before she herself was eliminated by Sasha Banks, with her team ultimately losing the match.
On January 28, 2018, Naomi competed in the inaugural women's Royal Rumble match at the 2018 Royal Rumble, entering at number 20 and lasting 06:49 before she was eliminated by Nia Jax. On the WrestleMania 34 kickoff show, Naomi went on to win the inaugural WrestleMania Women's Battle Royal by eliminating Bayley. In June, Naomi competed in her first Money in the Bank ladder match at the Money in the Bank pay–per–view, where she and the other six competitors were defeated by Alexa Bliss. In September, Naomi aligned with Asuka, and the two began a rivalry against The IIconics (Billie Kay and Peyton Royce). This led to a tag team match between the two teams on October 6 at WWE Super Show-Down, where Asuka and Naomi were defeated. Three weeks later, she took part in the first ever all women's pay–per–view, Evolution on October 28, competing in a women's battle royal match, which was won by Jax. In November at Survivor Series, Naomi competed in a traditional elimination tag team match as part of Team SmackDown, where she was the first woman eliminated from the match by Tamina. In December, Naomi received her first title shot in over a year as she unsuccessfully challenged her former ally Asuka for the Smackdown Women's Championship.
Towards the end of 2018, Naomi started a feud with Mandy Rose after Rose started flirting with Naomi's real-life husband, Jimmy Uso, who later revealed is only doing it because of Naomi's attitude towards her in Tough Enough from 2015. Naomi then went on to lose to both Rose and her partner Sonya Deville in two singles matches. At the Royal Rumble on January 27, 2019, the rivalry between Naomi and Rose continued as both women eliminated each other during the event's women's Royal Rumble match. In February, while she continued her feud with Rose, Naomi also started teaming up with Carmella. Naomi and Carmella competed in a six–team Elimination Chamber match for the inaugural WWE Women's Tag Team Championship at the namesake pay–per–view, where they were the first team eliminated.
On April 15, during the 2019 WWE Superstar Shake-up, Naomi was drafted to Raw. Shortly after she racked up victories against various opponents. Naomi was announced as one of the competitors for the Money in the Bank ladder match at the namesake pay–per–view that took place on May 19, however, Naomi was unsuccessful in winning the match.
On January 26, 2020, Naomi returned from a six month hiatus by entering the third Women’s Royal Rumble at number 18, where she lasted 22 minutes and survived to the final five before being eliminated by NXT's Shayna Baszler. On February 27, 2020, Naomi made history at Super ShowDown by becoming one half of the first women to participate in a women's championship match in Saudi Arabia against Bayley in a losing effort. In April at WrestleMania 36, Naomi competed in a five-way elimination match for the same title, during which she was eliminated by Sasha Banks. In September, she underwent surgery.
As part of the 2020 draft in October, Naomi was drafted back to the Raw brand. On January 31, 2021, Naomi returned from a injury by entering the fourth women’s Royal Rumble at number two, but was eliminated by Shayna Baszler and Nia Jax. On the February 1 episode of Raw, Naomi alongside Lana, defeated the teams of Asuka and Charlotte Flair and Dana Brooke and Mandy Rose to earn a future title match for the Women's Tag Team Championship. On the March 29 episode of Raw, she defeated Shayna Baszler in a singles match. She and Lana were then inserted into a tag team turmoil match on night one of WrestleMania 37 to determine the number one contenders for the WWE Women's Tag Team Championship on night two against Nia Jax and Shayna Baszler. After a short hiatus and Lana being released from her contract, Naomi made her return on the August 27 edition of SmackDown, confronting Sonya Deville backstage. After weeks of tension with Sonya Deville, demanding her for a match, Naomi lost to Deville and Shayna Baszler in a handicap match on the October 25 episode of SmackDown. Naomi finally defeated Sonya Deville on the January 28, 2022 episode of SmackDown. Naomi and Deville then eliminated each other from the Royal Rumble match at the namesake event the next night. Naomi teamed up with Ronda Rousey to defeat Deville and Charlotte Flair at Elimination Chamber the next month.
On the February 25 edition of SmackDown, Naomi announced that her and Sasha Banks were going to challenge for the WWE Women's Tag Team Championship, thus reuniting Team B.A.D. as a duo. On the subsequent episode of Raw, reigning champions Carmella and Queen Zelina would accept their challenge, consequently setting up the match for WrestleMania 38 night two. Over the following weeks, the respective teams of Rhea Ripley and Liv Morgan, and Natalya and Shayna Baszler would be added to the bout, thereby making it a fatal four-way tag team match. At the event, Naomi and Banks were successful in their pursuit, becoming the first African-American women’s tag team champions in WWE. During the May 16 episode of Raw, Naomi and Banks left the building before their scheduled match; it was announced later that week on SmackDown that Naomi and Banks had been suspended indefinitely and that the titles had been vacated.
In March 2023, after almost a year of inactivity, Naomi announced her departure from WWE.
On January 27, 2024, at the Royal Rumble pay-per-view, Naomi made her return to WWE by marking her first appearance within the company in nearly two years as a surprise entrant in the women's Royal Rumble match, where she entered at number two and lasting one hour and two minutes before being eliminated by Jade Cargill. On February 2, Naomi was officially assigned to SmackDown, signing a contract with the brand. Two weeks later, Naomi had her first singles match back in WWE, defeating Alba Fyre to qualify for the women’s Elimination Chamber match. On February 24, at Elimination Chamber: Perth, Naomi was unsuccessful in the match, as she was eliminated by Tiffany Stratton. On night one of WrestleMania XL, Naomi teamed with Jade Cargill and Bianca Belair to defeat Damage Control (Asuka, Kairi Sane and Dakota Kai) in a six-woman tag team match. After defeating Stratton to become number one contender to the WWE Women's Championship, Naomi faced Bayley for the title on the April 19 episode of SmackDown, where Stratton interfered and caused a disqualification. This led to a triple threat match for the title at Backlash France, where Naomi was unsuccessful. On the June 28 episode of SmackDown, Naomi defeated Blair Davenport and Indi Hartwell to qualify for the women’s Money in the Bank ladder match, though she was unsuccessful at the namesake event. After pinning WWE Women's Champion Nia Jax in a previous encounter, Naomi faced Jax for the title on the November 15 episode of SmackDown, but was unsuccessful after interference from Tiffany Stratton and Candice LeRae.