Young wrestled for the WWWF in two matches in 1969 and 1972.
Young made her World Wrestling Federation (WWF) return on the September 9, 1999 episode of SmackDown!, seated at ringside with The Fabulous Moolah. Jeff Jarrett invited Moolah into the ring and smashed a guitar over her head and then put Mae into the figure-four leglock for trying to help her. After this appearance, both Mae and Moolah began appearing regularly on WWF televised shows. Mae made her WWF in-ring debut on the September 27 episode of Raw is War; along with Moolah, she competed in a handicapped evening gown match against WWF Women's Champion Ivory, who stripped Mae from her gown before Moolah picked up the victory. At No Mercy on October 17, Mae managed Moolah, who defeated Ivory for the championship. At Survivor Series on November 14, she and Moolah competed in an eight-woman tag team match along with Debra and Tori against Ivory, Jacqueline, Terri Runnels, and Luna Vachon, with their team coming out victorious.
At the Royal Rumble event on January 23, 2000, Mae Young won the Miss Royal Rumble 2000 swimsuit contest and afterwards flashed her breasts. At the end of 1999 and through 2000, Mae developed a storyline along with "Sexual Chocolate" Mark Henry where she started dating him, which included a kayfabe pregnancy and attacks by The Dudley Boyz, specifically Bubba Ray Dudley, who performed powerbombs on Young through tables twice in consecutive episodes of Raw – the first being in the ring and the second, in which Young was originally bound to a wheelchair, being off the entryway stage as what has been described as the most notorious powerbomb in WWE history. Her child was eventually delivered and found to be nothing more than a bloody rubber hand. On April 2, Mae accompanied The Kat at WrestleMania 2000 to her match against Terri Runnels; Kat lost the match as Mae was distracted by kissing the guest referee, Val Venis, before attacking Terri and her manager, Moolah.
On December 24, 2001, Young and Moolah appeared backstage on the Christmas Eve edition of Raw, which marked their last appearance before returning in the summer of 2002.
On the July 29, 2002 episode of Raw, Mae Young returned along with Moolah, to promote her new book: "The Fabulous Moolah: First Goddess of the Squared Circle" before being attacked by 3-Minute Warning on orders of general manager Eric Bischoff. On the September 15, 2003 episode of Raw, she accompanied Moolah in her last wrestling singles match, in which she defeated Victoria before being attacked by Randy Orton and an infuriated Victoria. On June 15 at Bad Blood, Mae appeared during a segment along with Stone Cold Steve Austin and Eric Bischoff where she stripped herself in the ring and performed a bronco buster on Bischoff before being stunned by Austin.
On the September 23 episode of SmackDown!, Young teamed with Moolah and defeated Dawn Marie and Torrie Wilson.
On January 8, 2006 at New Year's Revolution, Young re−appeared along with Moolah during a bra & panties gauntlet match where she stripped herself before being attacked by Victoria as she left the ring, which led to both women retaliate and rip off Victoria's shirt. At WrestleMania 22 on April 2, Young appeared along with Moolah during a backstage segment with Snitsky.
At WrestleMania 23 on April 1, 2007, Mae Young appeared during a backstage segment along with several other WWE superstars and Hall of Famers. On the August 24 episode of SmackDown, Mae Young made a special appearance winning a Divas bikini contest. Mae's last appearance with Moolah before her death came at SummerSlam in August 2007, both appeared during a backstage segment along with Vince McMahon and Raw's general manager, William Regal, two months prior to her friend's death.
On March 29, 2008, Young was inducted into the WWE Hall of Fame as part of the 2008 class. At the ceremony, she was inducted by fellow wrestler Pat Patterson. The next night at WrestleMania XXIV, she appeared during transmission while she was introduced as part of the 2008 Hall of Fame class. On the 800th episode of Raw on November 3, Mae Young competed in a 16-Diva tag match, where she was pinned by Beth Phoenix; this was her final match.
At WrestleMania XXV on April 5, 2009, Mae Young appeared during transmission as the special guest time keeper for the 25-Diva battle royal, which was won by Santina Marella.
On the November 15, 2010, "Old School" edition of Raw, Mae Young won a Falls Count Anywhere handicap match against LayCool, thus becoming the first person ever to wrestle over the age of 80.
At WrestleMania XXVII on April 3, 2011, Mae appeared backstage during a segment along with The Rock and Eve Torres. During the May 2 episode of Raw, Vickie Guerrero and Dolph Ziggler mockingly presented Mae was a "birthday gift" to The Rock, who responded by kissing Young.
Mae Young appeared on SmackDown: Blast from the Past on April 10, 2012, kissing The Great Khali and Raw 1000 on July 23, 2012, during which she was escorted by a man dressed in a giant hand costume, claiming to be her son. On the September 24 episode of Raw, Mae appeared in one of Kane and Daniel Bryan's "Anger Management" skits. On the December 31 episode of Raw, Mae Young was warming up for her match with then-Divas Champion Eve Torres and began experiencing stomach cramps as it was later determined that she was once again pregnant and gave birth to "Baby New Year", played by Hornswoggle.
In her last on-screen appearance on the March 4, 2013 episode of Old School Raw, Mae Young's 90th birthday celebration was interrupted by CM Punk.
On January 9, 2014, Young passed away. On January 14, 2014, the exact day of Mae's death, WWE paid tribute to her with a posthumous video which included highlights of her career, and another one six days later on January 20.
On March 20, 2017, WWE honored Young during their Women's History Month; a video was released where she was credited as the women pioneer of professional wrestling and was praised for her contributions to the wrestling business by Stephanie McMahon, the late Fabulous Moolah, Ivory, Beth Phoenix and Pat Patterson. On July 30, multiple superstars from the Mae Young Classic recognized and honored Mae's legacy and life, among them Lita, Jim Ross, Lacey Evans, Mercedes Martinez, Bianca Belair, Marti Belle and Vanessa Borne.