In December 1988, Vachon participated in her only American Wrestling Association (AWA) pay-per-view matchup, at SuperClash III in a battle royal.
Luna's first WWF appearance was in April 1993 at WrestleMania IX, accompanying Intercontinental Champion Shawn Michaels in his match against Tatanka, who was accompanied by Michaels' former valet Sensational Sherri. After the match, Luna attacked Sensational Sherri at ringside and later in the first aid area, starting a vicious feud between the two.
At the same time Luna and Sherri were at odds, Bam Bam Bigelow had a confrontation with Sherri. This led to him being attacked by Tatanka and the two of them feuding. Soon after, Bam Bam (kayfabe) announced that he had fallen in love and presented Luna as his "main squeeze". He also endearingly called her his "Tick", which fans combined with her name to the chant "Luna-tic". From then, Bam Bam was seen blowing kisses to Luna at the end of matches, and in her honor even included the moonsault, redubbed Lunasault, into his repertoire. A mixed tag team match between the two pairs was planned for SummerSlam in 1993, but had to be canceled because Luna legitimately injured her arm and then Sherri left the WWF. Instead, Bigelow and The Headshrinkers fought and lost to Tatanka and The Smokin' Gunns in a six-man tag team match. In the autumn of 1993, Bam Bam and Luna ran afoul of some practical jokes from Doink the Clown, leading to a Survivor Series style match at the 1993 event of the same name, pitting Bam Bam, The Headshrinkers, and Bastion Booger against four Doinks (actually Men on a Mission and The Bushwhackers in clown makeup). During this time Luna was the cause of dissension between Bam Bam and his part-time tag team partner Bastion Booger, who had also (kayfabe) fallen in love with her. At WrestleMania X, Bam Bam and Luna finally got their revenge on Doink by beating the clown and his midget side-kick Dink in a mixed tag team match.
When the WWF's women's division was revived, Alundra Blayze won the Women's Championship. Luna set her eyes on the title and had a series of matches with Alundra, all resulting in victories for Blayze. It was during this time the relationship between Luna and Bam Bam first showed cracks after interference in a match backfired. In the summer, Luna sold Bam Bam's contract to Ted DiBiase, who was beginning to build his "Million Dollar Corporation". Luna then picked Japanese wrestler Bull Nakano to win the Women's title from Blayze, which she eventually did. Luna, however, left the WWF shortly after this title match.
In 1994, Luna was the first woman to appear in a WWF video game, when she was included in WWF Raw.
In 1994, she entered Extreme Championship Wrestling (ECW). She was brought in as Tommy Dreamer's new valet in his long running feud with Raven. While in ECW, Luna would stand with Tommy, feuding with Raven and his lackeys, which included Stevie Richards and The Vampire Warrior (who, in kayfabe, had become jealous of the time she was spending with Dreamer). She had more than a few physical confrontations with Richards, including a steel cage match, which she won.
In early 1997, Luna had a short run with World Championship Wrestling (WCW), again going after her rival Madusa. Luna interfered in Madusa's matches against WCW Women's Champion Akira Hokuto, preventing a title win by Madusa. Luna and Madusa met each other in a series of matches, including a match at the 1997 Slamboree. Although Luna dominated the matches, Madusa managed to get the pinfall every time.
Later in 1997, Luna returned to the WWF, first as Goldust's manager, helping him to reinvent himself as "The Artist Formerly Known as Goldust". The pair sported a variety of different outfits and roles, including a dominatrix, a slave, a "New Year Baby", and his nurse. Their first feud was against Vader. Luna's first appearance had her wheeling the allegedly paralyzed Goldust to the ring and then blinding Vader with some "medical fluid". Later when Goldust, dressed like a Christmas tree, recited poems in the ring, he was attacked by Santa Claus, who turned out to be Vader. Vader eventually defeated Goldust at the 1998 Royal Rumble. The Goldust/Luna pairing also took to imitating other wrestler's gimmicks, often those of Goldust's opponents. At one point Goldust and Luna impersonated European Champion Triple H and Chyna in a title match against Owen Hart. What Triple H had intended as a joke resulted in Owen beating Goldust and Commissioner Slaughter awarding the title to Hart, considering Goldust to be a legit replacement.
At this time, Goldust also teamed up with Marc Mero, which led to another feud, as Luna and Mero's valet Sable started to fight outside of the ring. The feud culminated in a mixed tag team match at WrestleMania XIV, pitting the two couples against each other. After this, Luna challenged Sable to an Evening Gown match at Unforgiven and scored the victory by stripping her opponent down to her underwear.
In August 1998, Luna had apparently patched up her differences with Sable, as the latter, now split from Marc Mero, introduced her as the newest member of the Human Oddities stable. Luna attacked Marc Mero's new valet Jacqueline. Luna scored a pinfall victory in August, but lost a rematch in September. In December, Sable, who had won the reinstated WWF Women's Championship, was attacked by the masked "Spider Lady", who turned out to be Luna. She justified her heel turn and attack towards her partner with the words: "It's about me, it's about what I deserve." In this feud against Sable, Shane McMahon personally supported Luna's efforts to win the championship after taking personal offense to Sable's attitude towards him and booked a Leather Strap match at the Royal Rumble. Leading up to that event, in the storyline, Luna was repeatedly attacked by an obsessed Sable fan. At the Royal Rumble, Sable successfully retained the title thanks to the interference of that fan, who now entered WWF competition as Tori. During the weeks prior to the Royal Rumble, Luna also defeated Gillberg. Luna was due to challenge Sable for another title shot several weeks later at St. Valentine's Day Massacre, but the match was canceled due to Luna's suspension.
Six months later, Luna returned at SummerSlam, chasing then Women's Champion Ivory backstage after a successful title defense against Tori. This started a feud between the two with Luna even scoring a pinfall victory during an impromptu, non-title match. At Unforgiven, however, she lost to Ivory in a Hardcore Rules match. During that feud, Luna also answered a challenge from then Intercontinental Champion Jeff Jarrett and defeated him via disqualification, thanks to Ivory's interference.
From then on, Luna began managing Gangrel, participating in several mixed tag team matches and helping Gangrel beat his opponents.
At Survivor Series in 1999, she joined forces with her former rivals Ivory, Jacqueline, and Terri Runnels, against Tori, Debra, The Fabulous Moolah, and Mae Young. Luna's team was defeated when Moolah pinned Ivory. At the Royal Rumble in 2000, she participated in the Swim Suit Contest, though in protest against the whole event she refused to take off her gown. Vachon then became involved in a brief feud with Jacqueline after the latter had pinned Harvey Wippleman to capture the Women's title. She was the first person to challenge Jacqueline on the February 7 edition of Raw, but failed following a German suplex. Gangrel, who accompanied her to ringside, responded by executing his Impaler DDT on the champion. This led to a mixed tag on the following episode of SmackDown, in which Vachon and Gangrel defeated Jacqueline and her partner Prince Albert. She was later released from the WWF in early 2000.
On August 27, 2010, Vachon passed away.
In 2019, Vachon was posthumously inducted into the WWE Hall of Fame as part of their Legacy wing.