In March 2017, Sane signed a three-year contract with WWE. On June 30, a video at a WWE house show in Tokyo, introduced Sane to WWE's developmental division, NXT, as well as the upcoming Mae Young Classic tournament. On July 13, she defeated Tessa Blanchard in the tournament's first round in her WWE debut match. The following day, Sane first defeated Bianca Belair in the second round, then Dakota Kai in quarterfinals and finally Toni Storm in the semifinals to advance to the finals of the tournament. Reportedly, Sane suffered both a concussion and a neck injury during the tapings. On September 12, Sane defeated Shayna Baszler in the tournament finals and thereby earned a shot at the vacant NXT Women's Championship at the next NXT TakeOver show.
In October 2017, Sane made her television debut on NXT, defeating Aliyah. In November, at NXT TakeOver: WarGames, Sane competed in a fatal four–way match for the vacant NXT Women's Championship. but was unsuccessful as Ember Moon won the match. On January 28, 2018, at the Royal Rumble, Sane participated in the first women's Royal Rumble match, entering at number 6 and lasting around 5 minutes before being eliminated by Dana Brooke. A few months later, she also participated in the WrestleMania Women's Battle Royal at WrestleMania 34, alongside other NXT superstars, but was eliminated from the match by Sasha Banks. Shortly after, Sane started a feud with Lacey Evans as the two exchanged victories and attacked each other throughout the next few weeks. Eventually, Sane was able to defeat Evans on the June 6 episode of NXT, in a final match between the two, to end their feud.
In July, after she defeated Candice LeRae and Nikki Cross in a triple–threat match to become the number one contender, Sane reignited her rivalry with Shayna Baszler, as the two exchanged victories in the Mae Young Classic Finals and at NXT and faced off in a match at NXT TakeOver: Brooklyn IV on August 18 where Sane was able to defeat Bazsler to win the NXT Women's Championship for the first time in her career. On October 28, at the WWE Evolution pay–per–view, Sane lost the championship back to Baszler (after interference from her allies Jessamyn Duke and Marina Shafir) ending her reign at 71 days. Three weeks later, at NXT TakeOver: WarGames, Sane received her rematch against Baszler in a two out of three falls match, but she failed to regain the title after interference from Duke and Shafir again. Because of the interferences, Sane eventually aligned with her best friend Io Shirai and Dakota Kai against Baszler, Duke and Shafir. Shortly after, Kai was sidelined with an injury and Sane continued to team with Shirai, forming a tag team known as "The Sky Pirates" while continuing to defeat various teams.
On April 5, 2019, at NXT TakeOver: New York, Sane competed in a fatal–four way match for the NXT Women's Championship, however, she was unsuccessful in capturing the title as Baszler submitted Bianca Belair to retain. Just six days later, on April 11 (episode aired on tape delay on April 17), Sane lost a rematch to Baszler after Io Shirai attacked Baszler who was looking to injure Sane. Because of her loss, Sane was not allowed to challenge for the NXT Women's Championship anymore, which was a way to write her off the brand.
On April 16, 2019, during the 2019 WWE Superstar Shake-up, Sane was introduced by Paige to the SmackDown brand where she formed a tag team with Asuka called the Kabuki Warriors, managed by Paige. In her first match as part of the brand, Sane picked up a victory for her team in an eight–woman tag team match. Throughout the following weeks, Sane and Asuka started a feud with The IIconics (Billie Kay and Peyton Royce) over their WWE Women's Tag Team Championship. After weeks of dodging by the IIconics, the Kabuki Warriors were granted their title match on the July 16 episode of SmackDown which they won by count out however, the IIconics retained their titles. On the August 5 episode of Raw, the Kabuki Warriors participated in a fatal four way elimination tag team match for the Women's Tag Team Championship but were the last ones eliminated by Alexa Bliss and Nikki Cross after Sane got pinned by Bliss.
After a short hiatus, The Kabuki Warriors returned in September and defeated Mandy Rose and Sonya Deville. On October 6, at the Hell in a Cell pay-per-view, The Kabuki Warriors finally won the Women's Tag Team Championships from Bliss and Cross, after Asuka used a green mist on Cross. The next night on Raw, The Kabuki Warriors completed their transition into heels, as they cut a promo on both Becky Lynch and Charlotte Flair and went onto defeat them in a non-title match, once again using green mist as leverage. As part of the 2019 Draft in mid-October, Asuka and Sane were both drafted to the Raw brand. On the October 28 Raw, Sane and Asuka further cemented their heel turn when they turned on their manager Paige after Asuka sprayed green mist in her eyes. That same night, Sane went one-on-one with Becky Lynch, which she lost by submission. On the October 30th episode of NXT, The Kabuki Warriors faced Tegan Nox and Dakota Kai for the WWE Women’s Tag Team Titles - making it the first time the titles were defended on NXT - which they retained. On the November 4 episode of Raw, The Kabuki Warriors lost to Flair and Natalya when Asuka submitted to Natalya. The following week, Sane and Asuka retained their titles against Lynch and Flair following an interference from Shayna Baszler and Bayley.
Sane represented Team Raw at Survivor Series in a 5-on-5-on-5 elimination tag team match, being eliminated by Sasha Banks. On December 1 at WWE Starrcade, The Kabuki Warriors successfully retained the tag team titles against Becky Lynch and Charlotte Flair, Alexa Bliss and Nikki Cross and Bayley and Sasha Banks when Asuka submitted Cross. On the December 2 episode of Raw, Sane and Asuka defeated Charlotte Flair when Sane pinned Flair. The following week on Raw, Sane and Asuka lost to Becky Lynch by disqualification when Asuka attacked Becky with a chair, and Sane performed an Insane Elbow on Lynch through a table. Sane and Asuka subsequently challenged Lynch and Flair to a match at TLC, to which they accepted. At TLC: Tables, Ladders and Chairs, The Kabuki Warriors retained their titles against Lynch and Flair, during the match, Sane suffered a concussion, which caused the remainder of the match to be changed on the fly. Following TLC, Sane would accompany Asuka on the entrance stage during a segment between Asuka and Lynch, but didn’t go to ringside with Asuka during her matches. Sane made her television return on the January 20 episode of Raw, losing to Lynch by submission. On the March 2 2020 episode of Raw, she returned to the ring in a losing effort against Shayna Baszler.
On the first night of WrestleMania 36, The Kabuki Warriors (Asuka and Kairi Sane) lost their Women's Tag Team Championship to the team of Nikki Cross and Alexa Bliss. This ended their reign at 181 days.
On the May 11, 2020 episode of Raw, then-Raw Women’s Champion Becky Lynch vacated her title in order to take maternity leave, revealing that Asuka won the championship the night before by winning the Money in the Bank ladder match at the eponymous event. On the next episode of Raw, after Lynch's announcement, Sane was seen backstage with some of the other wrestlers congratulating Lynch, thus turning The Kabuki Warriors face as Sane celebrated Asuka’s championship victory before being interrupted by Nia Jax, thus beginning a feud. On the June 6 episode of Raw, which was taped on May and aired on tape delay, Sane suffered a significant head cut. Sane made her televised return since her injury on the July 6 episode of Raw, as she challenged Sasha Banks in a match that ended in a disqualification due to Bayley's interference. Weeks after, The Kabuki Warriors unsuccessfully challenged Banks and Bayley for the WWE Women's Tag Team Championship. On the July 20 episode of Raw, she defeated SmackDown Women's Champion Bayley in a non-title match. The following week on Raw, Sane was viciously assaulted by Bayley backstage during the Raw Women's Championship match between Asuka and Banks. This was done to write her out of the storylines as Sane confirmed her departure from WWE later that night.
Sane made her WWE return at Crown Jewel on November 4, 2023, in which she assisted Iyo Sky in retaining the WWE Women's Championship against Bianca Belair, therefore joining the SmackDown brand. On the following episode of SmackDown, Sane confronted Bayley and forgave her for her actions back in 2020 and joined Damage Control. On the same episode, during a six-woman tag team match pitting Asuka with Belair and Charlotte Flair against Damage Control (Bayley, Sky and Sane), Asuka turned on her teammates to reunite with Sane while joining Damage Control at the same time. At Survivor Series WarGames, Damage Control lost to Bianca Belair, Charlotte Flair, Becky Lynch, and Shotzi in a WarGames match. On the January 26, 2024 episode of SmackDown, Sane and Auska defeated Kayden Carter and Katana Chance to win the WWE Women’s Tag Team Championships for the second time as a team and Sane’s second time individually. Sane then competed in the 2024 Royal Rumble match, entering the match at number eleven and eliminating Candice LeRae before being eliminated by Kayden Carter. On the Elimination Chamber: Perth pre-show, Sane and Asuka defended their titles against the team of Indi Hartwell and LeRae. At NXT Roadblock, they defeated the team of Lyra Valkyria and Tatum Paxley to retain their titles. On night one of WrestleMania XL, Damage Control (Sane, Asuka, and Kai) were defeated by Bianca Belair, Naomi, and Jade Cargill in a six-woman tag team match. During the 2024 WWE Draft, Sane (as a part of Damage Control) was drafted to the Raw brand. At Backlash France, Sane and Asuka lost their titles to Belair and Cargill, ending their second reign at 99 days.