In 1999, Noble joined World Championship Wrestling. He made his first appearance with the promotion on July 11, 1999, under the ring name Jamie Howard, teaming with Jet Jaguar in a loss to CG Afi and Jeremy Lopez in a dark match at Bash at the Beach. He made his televised debut on the September 28, 1999 episode of WCW Saturday Night, defeating Alan Funk. He went on to perform in the promotion's cruiserweight division.
In February 2000, Noble was renamed "Jamie-San" and reintroduced to WCW television as a member of the East Asian stable The Jung Dragons, with Noble wearing a mask to conceal the fact that he was Caucasian. The stable was made up of Jamie, Jimmy Yang, Kaz Hayashi and their valet, Leia Meow. Throughout mid-2000, The Jung Dragons feuded with rival stable 3 Count. He made his pay-per-view debut at New Blood Rising on August 13, 2000, with The Jung Dragons losing to 3 Count in a double ladder match.
In November 2000, Noble left The Jung Dragons and formed a tag team with former 3 Count member Evan Karagias. He removed his mask and adopted the ring name Jamie Knoble, with he and Karagias performing as "Noble and Courageous". Noble and Courageous feuded with the remaining members of The Jung Dragons and 3 Count. Knoble continued to wrestle for WCW until the promotion was purchased by the World Wrestling Federation in March 2001.
Knoble debuted in the WWF, now renamed WWE, on the June 6, 2002 episode of SmackDown! by attacking the Hurricane and was joined by Nidia in a trailer park trash gimmick. The spelling of his ring name was tweaked to Jamie Noble a few weeks afterwards. He won the WWE Cruiserweight Championship and feuded with Tajiri and Billy Kidman. Noble held the title for 147 days, until he lost the title to Billy Kidman at WWE Survivor Series on November 17, 2002. Noble then got an inheritance, making both Nidia and Noble rich. Noble and Nidia both turned face by befriending Torrie Wilson and Billy Gunn. Nidia finally left him after she was "blinded" by then-heel Tajiri's black mist. He became a heel again by doing things he thought Nidia could not see (mainly using her as a human shield) and lied to her about them. During that time, he also feuded with Rey Mysterio for the Cruiserweight Championship. The two would face off for the championship and Noble lost. A boyfriend versus girlfriend blindfold match was then scheduled for Noble and Nidia at No Way Out. Noble came out on top after cheating to see where Nidia was. He left WWE on September 15, 2004.
Noble made his return to WWE on the December 17, 2005 episode of Velocity and would later frequently team up with fellow cruiserweight Kid Kash; during June 2006, Noble and Kash debuted a gimmick, where they wore dog collars, and barked and bit, and had a short face run. The pair quickly turned heel and were soon named "The Pitbulls". They then entered the hunt for the WWE Tag Team Championship. The Pitbulls disbanded after Kash was fired from WWE on September 27, 2006.
In 2007, Noble returned to competing in the cruiserweight division and performing as an enhancement talent against Rey Mysterio and Bobby Lashley. At No Way Out, Noble competed in a cruiserweight gauntlet match for the WWE Cruiserweight Championship. He was eliminated by his former WCW teammate, Jimmy Wang Yang.
Noble returned to television on the June 8 episode of SmackDown!, teaming up with Chavo Guerrero and Daivari against Paul London, Brian Kendrick and Wang Yang in a losing effort. On the June 15 episode of SmackDown!, Noble competed in a fatal four-way number one contenders match for the Cruiserweight Championship, which he lost to Jimmy Wang Yang and also involved Shannon Moore and Daivari. In July, Noble was unsuccessful in a triple threat match for the Cruiserweight Championship against then-champion Guerrero and Funaki. Noble then competed in the Cruiserweight Open at The Great American Bash, but was pinned by Hornswoggle. Noble would then begin a feud with Hornswoggle that would see him lose in various humiliating fashions, usually by countout. Moore would constantly use his obsession with Hornswoggle to humiliate him as well.
After his feud with Hornswoggle ended, Noble began an angle where he was easily defeated in his matches as punishment for being disrespectful to then-SmackDown! general manager, Vickie Guerrero. He was eventually placed in a match with Chuck Palumbo, which was expected to be yet another squash. Noble, however, defeated Palumbo, which began a feud between the two, as well as involving Palumbo's "friend" Michelle McCool. After his fourth win against Palumbo, he came out when Chuck threatened to hurt McCool. Later in a tag team match, Palumbo attacked Noble and McCool, becoming a heel in the process. As a result of the double turn, Noble became a face character once again.
As part of the 2008 WWE Supplemental Draft, Noble was drafted to the Raw brand. Noble was then involved in a storyline where he tried to impress Layla on multiple occasions, only to antagonize and be beaten by larger opponents. He started a feud with William Regal over the course of the storyline, with the two trading wins, and Layla, between them. On the September 15, 2008 episode of Raw, the feud escalated following Noble's victory over Paul Burchill. Layla came out and told Noble it was over and she found a man worthy of her in Regal.
On the February 3 episode of ECW, Noble asked then-ECW General Manager Theodore Long for an ECW contract, but lost to The Boogeyman.
On the February 23 episode of Raw, Noble suffered a neck injury in a match with Mike Knox. Noble made his return about one month later. During a match with Sheamus on the November 2, 2009 episode of Raw, Noble sustained a severe back injury after landing badly from a fall out of the ring. On November 10, 2009, Noble announced he was retiring from professional wrestling due to the effects of the injury and several other nagging injuries sustained over his career.
Upon retiring, Noble began working as a producer. He made occasional appearances on WWE programming and wrestled sporadically at house shows, including a bout with World Heavyweight Champion Daniel Bryan on January 13, 2012.
On the September 29, 2014 episode of Raw, Noble and fellow producer Joey Mercury aligned themselves with the villainous stable The Authority. They were later named "J&J Security", with Noble and Mercury acting as bodyguards to Authority member Seth Rollins. On the November 24 episode of Raw, Noble, along with Mercury, would wrestle their first televised matches in several years, when they teamed up with Rollins in a 3-on-2 Handicap match against John Cena and Dolph Ziggler in a losing effort. On the February 5, 2015 episode of SmackDown, J&J Security once again teamed with Rollins, this time in a 3-on-1 handicap match against Daniel Bryan, once again in a losing effort. After weeks of tension between Rollins and The Authority, on the June 8 episode of Raw, J&J Security stood up to Rollins, leaving him, before defeating Rollins in a 2-on-1 Handicap match following interference from Dean Ambrose. However, on the June 22 episode of Raw, after Rollins apologized to The Authority for his behavior and Brock Lesnar returned and attacking him, J&J Security and Kane would help Rollins attack Lesnar. Noble would legitimately suffer three broken ribs from Lesnar after being thrown into the barricade during the brawl. On the July 6 episode of Raw, Brock Lesnar viciously attacked J&J Security, whom an afraid Rollins sent to the ramp to stop him from getting his hands on Rollins by confronting him near their new Cadillac, which Rollins had just given them as a gift of his appreciation the previous week. Noble was promptly beaten down by Lesnar and locked into a Kimura Lock submission maneuver. Following this, it was announced that both Noble and Mercury would be out of action indefinitely.
In 2017, Noble was seen backstage at Great Balls of Fire, assisting Raw General Manager Kurt Angle with the rescue of Braun Strowman, who had been trapped in an ambulance due to Roman Reigns crashing into it with a truck, following their ambulance match. On the May 29, 2018 episode of Raw, Noble helped Seth Rollins after he was attacked by Elias. On the May 29, 2020 episode of SmackDown, Noble was among officials on the scene following a hit-and-run on Elias and found a seemingly inebriated Jeff Hardy, who was then arrested. On the March 12, 2021 episode of SmackDown, Noble was seen shielding Cesaro from Seth Rollins, who attacked him.