In 1983, while teaming in WCW, Gerald and his brother Jack Brisco arrived as heels against the team of Ricky Steamboat and Jay Youngblood, the WCW World Tag Team Champions.
The two teams traded the belts back and forth until the feud culminated at the first Starrcade, with Steamboat and Youngblood regaining the championship. The brothers would hold the title one last time in 1984, ultimately losing to the team of Wahoo McDaniel and Mark Youngblood. They would leave WCW shortly after.
The brothers entered the World Wrestling Federation in the fall of 1984, once again assuming their familiar role as fan favorites. The Briscos unsuccessfully challenged the North-South Connection, Adrian Adonis and Dick Murdoch, for the WWF World Tag Team Championship. Both men would retire from the ring in early 1985. After retiring, Brisco began working backstage as a road agent and booker for Vince McMahon.
Following the 1997 Montreal Screwjob, Brisco capitalized on his notoriety by becoming an onscreen "stooge" of Vince McMahon along with Pat Patterson. The duo portrayed a pair of bumbling comic heels and joined The Corporation and the McMahon-Helmsley Faction. They lampooned Hulk Hogan by mimicking his trademark gestures and using "Real American", his old entrance theme.
On the May 18, 2000 episode of SmackDown! Brisco won his first WWF championship when he pinned a sleeping Crash Holly to win the perpetually contested Hardcore Championship. Crash regained the title on June 12, but Brisco was intent on regaining. Brisco eventually regained the title the following week with the aid of Pat Patterson in the midst of a match between Crash and his cousin, Hardcore Holly.
As Patterson and Brisco celebrated the victory, Patterson poured champagne in Brisco's eyes then broke a second bottle over his head. He then pinned the (kayfabe) unconscious Brisco to win the Hardcore Championship. Patterson hid from Brisco in drag in the women's locker room, and, after Brisco pursued him into the locker room, Vince McMahon booked them in a Hardcore Evening Gown Match at the King of the Ring. In the course of the match, Holly interfered and pinned Patterson, regaining the title once again.
He appeared at WrestleMania 23 in a party scene and also on the July 23, 2007 edition of Raw. On March 29, 2008, Brisco and his brother were inducted into the WWE Hall of Fame the night before WrestleMania XXIV in Orlando, Florida.
During the Raw Reunion episode on July 22, 2019, Brisco pinned Pat Patterson off-screen backstage to win the WWE 24/7 Championship. He became the third person to win both the WWE Hardcore Championship and the WWE 24/7 Championship. He would soon after lose the title to Kelly Kelly that same night.