Chyna made her WWF debut on February 16, 1997 at In Your House 13: Final Four; her character emerged as a plant from a ringside seat, choking Marlena while Goldust was in the ring with Triple H. Her original role in the promotion was as the laconic enforcer/bodyguard for D-Generation X, which was founded by Shawn Michaels and Triple H. She often helped them (then, a rising villain) cheat to win by physically interfering in matches by executing her trademark low blow to the groin.
In January 1999, Chyna was the thirtieth entrant in the Royal Rumble, becoming the first woman ever to enter the eponymous match. The day after the Royal Rumble, Chyna became a villainess by betraying Triple H and aligning herself with his enemy Vince McMahon and Kane. Chyna teamed with Kane at the St. Valentine's Day Massacre pay-per-view against former allies X-Pac and Triple H. At WrestleMania XV, Chyna turned on Kane in his match by attacking him with a chair, appearing to rejoin DX. Chyna and Triple H, however, turned against DX later that evening when they helped Shane McMahon defeat DX member X-Pac. The duo became part of The Corporation and later Shane McMahon's Corporate Ministry. Following the dissolution of the Corporate Ministry, the villainous Chyna remained at Triple H's side. They would eventually split up later in the year.
In June 1999, Chyna became the first woman to qualify for the King of the Ring tournament. She was also the first female to be the number one contender for the WWF Championship, but lost the spot to Mankind before SummerSlam in August. Later that year, Chyna became a fan favorite again during her long feud with Jeff Jarrett. She challenged the British Bulldog to a match on the October 4, 1999 Raw, a match in which she defeated him. At Unforgiven, she had a match for the WWF Intercontinental Championship against Jarrett, which she lost. She defeated Jarrett for the title at No Mercy in his last WWF match, a Good Housekeeping match, on October 17, in the process becoming the first and only woman to win the Intercontinental Championship. She also gained the services of his valet, Miss Kitty.
Chyna then feuded with Chris Jericho over the belt, defeating him at Survivor Series, but losing the title to him at WWE Armageddon. The two faced off again in a match on the edition of December 28 of SmackDown!, which ended controversially with both wrestlers pinning each other. As a result, then "head of authority" Stephanie McMahon-Helmsley declared them co-champions. At the Royal Rumble, Jericho and Chyna defended the title against Hardcore Holly in a Triple Threat match to determine the Intercontinental Champion, which Jericho won; Chyna's "co-champions" reign is no longer recognized by WWE and is now considered a continuation of Jericho's second Intercontinental reign. Afterwards, Chyna briefly teamed with Jericho.
Not long after losing the Intercontinental title, Chyna became the on-screen girlfriend of Eddie Guerrero. Guerrero and Chyna, originally villains, later became fan favorites during the summer of 2000, with Guerrero dubbing her his "Mamacita". The couple faced Val Venis and then-rookie Trish Stratus in an intergender tag team match at SummerSlam with the Intercontinental Championship on the line. Chyna won the match, but lost the belt two weeks later to Guerrero in a Triple Threat match with Kurt Angle. They officially split in November 2000 after Chyna, in storyline, found Eddie cavorting in the shower with two other women.
Chyna, after posing for Playboy, then drew the ire of the Right to Censor (a group of morally conservative wrestlers). Shortly after, Chyna began a feud with Ivory, a member of the Right to Censor, over the Women's Championship. This culminated in a storyline at the Royal Rumble where Chyna appeared to reinjure her neck while performing a handspring back elbow. In order to better convince the audience that she was injured, color commentator Jerry Lawler left the commentators' booth and entered the ring to check on Chyna's condition. When Chyna returned from the "injury", she won the Women's Championship from Ivory at WrestleMania X-Seven in a squash match. Chyna also defended her title against Lita at Judgment Day in 2001. Although she won the match, she soon vacated the Women's Championship, as this was Chyna's final WWF match. She left the WWF on November 30, 2001, several months after she had been taken off of television.
Chyna passed away on April 17, 2016.
In 2019, Chyna was posthumously inducted into the WWE Hall of Fame as part of D-Generation X, alongside Triple H, Shawn Michaels, X-Pac, Road Dogg, and Billy Gunn.