Chase made his WWE debut during the July 2, 2021 episode of 205 Live, where he won an NXT Breakout Tournament qualifier match, defeating Guru Raaj.
Chase made his televised NXT debut on the July 20 episode, where he was eliminated in the first round of the NXT Breakout Tournament by Odyssey Jones. He returned to NXT television during September and wrestled regularly during the succeeding months. Chase's return saw him become the founder of "Chase University", with multiple vignettes of his classes being shown. With his student body motivating him from the stands, Chase suffered losses to Bron Breakker, Xyon Quinn, Cameron Grimes, and Tony D'Angelo. On the December 28 episode of NXT, Chase was defeated by Harland, however, Bodhi Hayward, a student of Chase U, attempted to save Chase from Harland. The pair then competed in the Dusty Rhodes Tag Team Classic, but were eliminated in the first round by the Grizzled Young Veterans (James Drake and Zack Gibson). Over the next few months, Chase University would also recruit Thea Hail and Chase would slowly turn face. On the September 20, 2022 episode of NXT, Chase and Hayward would pick up a victory over Carmelo Hayes and Trick Williams. This earned Chase an NXT North American Championship match qualifier against Von Wagner on the October 4 episode of NXT, but he was defeated.
In November, Hayward was released from his WWE contract, thus removing him from Chase University. On the November 1 episode of NXT, Duke Hudson would join Chase University, accompanying Andre Chase and Thea Hail as Chase U's flag bearer, and would save Chase from an attack by Charlie Dempsey. On the January 31, 2023 episode of NXT, Chase and Hudson defeated The Dyad and Edris Enofe and Malik Blade to earn a spot in the fatal four-way match for the NXT Tag Team Championship at NXT Vengeance Day. At the event, Chase U were unsuccessful in capturing the titles. On the June 27 episode of NXT, Chase returned after a short hiatus to help Hudson fight off Drew Gulak and Charlie Dempsey after Thea Hail was defeated by Tiffany Stratton.
On October 24, during night one of NXT Halloween Havoc, Chase and Hudson defeated The Family (Tony D'Angelo and Channing "Stacks" Lorenzo) to become the NXT Tag Team Champions, winning his first championship in WWE. Chase and Hudson would go on to lose the titles back to The Family on the November 14 episode of NXT, ending their reign at 22 days. At the end of 2023, Chase U began a storyline where it was revealed that the University was in heavy debt after Chase gambled away all their funds. On the January 23, 2024 episode of NXT, repo men were seen repossessing equipment from Chase U, including Hudson's MVP trophy, teasing the disbandment of Chase U. The following week, Jacy Jayne announced that she had created the "2024 Ladies of Chase U" calendar, which was launched at NXT Vengeance Day, and that the projected sales would save Chase U. Chase thanked Jayne and officially accepted her into the stable. In March, Jayne turned on Chase U, which led to a six-woman tag team match at NXT Stand and Deliver on April 6, with Hail teaming up with Fallon Henley and Kelani Jordan to defeat Jayne, Kiana James and Izzi Dame.
In early May 2024, Ridge Holland began associating himself with Chase U. On the May 14 episode of NXT, Holland challenged The O.C. (Luke Gallows and Karl Anderson) to a tag team match when The O.C. mocked Holland for leaving the main roster to NXT. Chase offered Riley Osborne to be Holland's tag team partner to Osborne's dissatisfaction. The O.C. won the match after another mishap from Holland. On the June 25 episode of NXT, Chase and Hudson won a tag team turmoil match for an NXT Tag Team Championship match at NXT Heatwave. At the event on July 7, Chase and Hudson failed to defeat Nathan Frazer and Axiom for the titles. Holland soon secured a rematch for the NXT Tag Team Championships, but it would be Chase teaming up with Holland instead of Hudson. On the August 13 episode of NXT, Chase and Holland defeated Frazer and Axiom for the NXT Tag Team Championships, making Chase a two-time champion. Chase and Holland lost the titles back to Frazer and Axiom nineteen days later at NXT No Mercy. After the match, Holland attacked the stable, defecting from Chase U and reverting back to a heel in the process. Chase returned on the October 15 episode of NXT to save Osborne from being taken out by Holland after their match. At NXT Halloween Havoc on October 27, Holland defeated Chase in an Ambulance match.