In 1979, The Wild Samoans (Afa and Sika) joined the World Wrestling Federation, where they were managed by Lou Albano and referred to as "Albano's Wildmen". The "wild" nature of the brothers was conveyed through their unorthodox behavior (which included communicating only in unintelligible grunts and consuming unprepared raw fish, during interviews and while approaching the ring). While in the WWF, The Wild Samoans won the WWF World Tag Team Championship. Both members also challenged Bob Backlund for the WWF Heavyweight Championship on several occasions. They left the promotion in 1980.
The Wild Samoans returned to the WWF (renamed from WWWF in 1979) in 1983 and regained the WWF World Tag Team Championship. After Sika suffered an injury, the tag team was supplemented by Afa's son Samu (the relationship was not acknowledged on TV). The trio remained in the WWF until 1984.
Afa Anoaʻi returned to the WWF for a third time in 1992, as the manager and occasional tag partner of The Headshrinkers (Samu and Fatu). He wrestled his final match on May 22, 1994, teaming with The Headshrinkers to defeat The Quebecers and Johnny Polo at the Rosemont Horizon. Anoaʻi left the WWF in mid-1995.
On March 31, 2007, the Wild Samoans were inducted into the WWE Hall of Fame by Samu and Sika's son, Rosey.
The Wild Samoans appeared at Hell in a Cell 2020 to celebrate Roman Reigns' victory.
Afa passed away on August 16, 2024, just two months after his brother Sika.